Use of calcium hydroxyapatite and growth factors in endodontic therapy

Background/Aim. Hydroxyapatite (HAp) is one of the most commonly used calcium phosphate bioceramics with osteoconductive properties. Growth factors are capable directly inducing morphological and functional differentiation neodontoblasts. The aim this study was to investigate effectiveness HAp-based biomaterial in combination transforming growth factor-?1 (TGF-?1) creation new dentine obturation root canal apex teeth an experimental animal model. Methods. Rodent (rabbit) were as After pulp removal a extirpator vital pulpectomy, applied using Lentulo spiral portion at level physiological foramen apicale. experiment performed general anesthesia. Animals kept alive for 3, 6, 12 months after treatment. extracted analyzed by scanning electron microscopy (SEM). Results. Using SEM, it found that number newly created greater Conclusion. Apex dental took place our groups treated or without TGF-?1.